Technology

Beacon Science Data Sheet

Beacon Sciences' Lock-and-Key Chemistry

No Need for Antibodies or Enzymes

While many biochemical assays require proteins, antibodies, or enzymes, Beacon Sciences uses a custom lock-and-key recognition chemistry combined with chromophore release to develop highly specific, stable, and inexpensive binding assays for a wide range of analytes. This unique approach simplifies the assay procedures by avoiding the need for costly antibodies or proteins, secondary labeling or chemical reactions, or complicated instrumentation.

Building on the pioneering work in supramolecular recognition by Dr. Eric Anslyn, Beacon Sciences creates entirely synthetic molecular pockets that selectively bind a target molecule. By embedding this pocket with a weakly-held fluorescent chromophore, this enables a displacement reaction to occur in the presence of the target molecule. Using the process of chemiluminescence, the displaced chromophore provides an optical signal that a binding event has occurred.

Beacon's rapid development time, high sensitivity, ease-of-use, and low costs meet the needs of many markets, including Environmental, Life Science Research, In Vitro Diagnostics, and Biodefense testing. In addition, these tests may also be used to supplement existing antibody- or enzyme-based tests.

How Chemiluminescence Works

Beacon Sciences has combined our novel molecular recognition techniques with the power of chemiluminescence to deliver custom, rapid, visible, cost-effective assays for our clients. Chemiluminescence is the emission of visible light resulting from radiation energy created by a chemical reaction in which multiple chemical compounds are mixed. A large release of energy occurs due to the reaction between the multiple compounds leading to the excitation of atoms in the materials. As a result, electrons rise to a higher energy level and then return to their normal levels. When the electrons return to their normal levels, they release energy as light.